The influence of the Ukrainian phytocomposition "Balm Truskavets'" on parameters of neuro-endocrine-immune complex and biophotonics in humans with maladaptation

FIHURA, Oksana, RUZHYLO, Sofiya, KORDA, Mykhaylo, KLISHCH, Ivan, ŻUKOW, Xawery & POPOVYCH, Igor. The influence of the Ukrainian phytocomposition "Balm Truskavets’" on parameters of neuro-endocrine-immune complex and biophotonics in humans with maladaptation. Journal of Education, Health and Sport. 2023;13(1):326-337. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2023.13.01.048 https://apcz.umk.pl/JEHS/article/view/41834 https://zenodo.org/record/7527810 The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 21, 2021. No. 32343. Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences). Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 21 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159. Przypisane dyscypliny naukowe: Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu). © The Authors 2023; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 28.11.2022. Revised: 15.12.2022. Accepted: 12.01.2023. The influence of the Ukrainian phytocomposition "Balm Truskavets'" on parameters of neuro-endocrine-immune complex and biophotonics in humans with maladaptation Oksana A. Fihura1,2 https://orcid.org/0000-0002-5711-0484, Sofiya V. Ruzhylo1 https://orcid.org/0000-0003-2944-8821, Mykhaylo M. Korda3 https://orcid.org/0000-0003-0676-336X, Ivan M. Klishch3 https://orcid.org/0000-0001-6226-4296, Xawery Żukow4 https://orcid.org/0000-0001-5028-7829, Igor L. Popovych5 https://orcid.org/0000-0002-5664-5591 1Ivan Franko State Pedagogical University, Drohobych, Ukraine oksanafigura08@gmail.com; doctor-0701@ukr.net 2Ukrainian Scientific Research Institute of Medicine of Transport, Odesa, Ukraine 3IY Horbachevs’kyi National Medical University, Ternopil’, Ukraine cordamm@yahoo.com; klishch@tdmu.edu.ua 4Medical University of Bialystok, Bialystok, Poland xaweryzukow@gmail.com 5Bohomolets’ Institute of Physiology of National Academy of Sciences, Kyїv, Ukraine i.popovych@biph.kiev.ua Abstract Background. Earlier we showed that the Ukrainian phytocomposition “Balm Truskavets’” exerts immediate modulating effects on parameters of EEG and HRV as well as biophotonics. In a pilot study on 10 volunteers, we found that the use of the phytocomposition for 11 days causes changes in EEGs parameters accompanied by a sympatho(adreno)mimetic effect. The modulating effects on the EEG&HRV parameters are combined with the changes in biophotonics parameters. This study was conducted on a four times larger cohort and with a wider range of methods. Materials and Methods. The object of observation were 16 women 46±15 ys and 24 men 50±11 ys. The volunteers were practically healthy, but the initial testing revealed deviations from the norm in a number of parameters of the neuro-endocrine-immune complex as a manifestation of maladaptation. The adaptation hormones levels, Popovych’s leukocytary adaptation and strain indices, parameters of phagocytosis, biophotonics, acupuncture points, EEG and HRV, before and after a 9-day course of use of phytocomposition registered. Results. A noticeable effect of the phytocomposition on 38 parameters was revealed, grouped into 6 clusters, of which 4 are enhancing and 2 are reducing. In particular, the reduced levels of the adaptation index and phagocytosis parameters increase significantly, instead, the increased levels of the strain index, testosterone, triiodothyronine, LF band HRV as well as two biophotonics parameters decrease, that is, there is a normalizing/beneficial effect. At the same time, normal levels of HRV-markers of vagal tone decrease, and cortisol and circulating catecholamines as well as the activity of β- and α-rhythm generating neurons increase, but within the normal range. Finally, there is a further increase in the upper limit levels of activity of δ-rhythm generating neurons. Conclusion. Ukrainian phytocomposition “Balm Truskavets’” exerts classical adaptogenic effects on parameters of neuro-endocrine-immune complex as well as biophotonics and acupuncture in humans with maladaptation. Keywords: phytocomposition “Balm Truskavets’”, neuro-endocrine-immune complex, biophotonics, acupuncture, maladaptation